New Criteria for `Obesity Disease' in Japan
The present study was designed to establish adequate criteria for categorizing 'obesity disease' in Japan in relation to obesity-related complications. The subjects were 1,193 J...
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453 publications
Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis
Schizophrenia is one of the most common, burdensome, and costly psychiatric disorders in adults worldwide. Antipsychotic drugs are its treatment of choice, but there is controve...
Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently s...
Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
Evolving definitions of frailty, and improved understanding of molecular and physiological declines in multiple systems that may increase vulnerability in frail, older adults ha...
Solitons in Optical Communications
Abstract Solitons are a fascinating topic for study and a major source of interest for potential application in optical communication. Possibly the first observation of a solito...
Minimum prediction residual principle applied to speech recognition
A computer system is described in which isolated words, spoken by a designated talker, are recognized through calculation of a minimum prediction residual. A reference pattern f...
Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle
The body-wide human microbiome plays a role in health, but its full diversity remains uncharacterized, particularly outside of the gut and in international populations. We lever...
Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020
As of April 2, 2020, the coronavirus disease 2019 (COVID-19) pandemic has resulted in >890,000 cases and >45,000 deaths worldwide, including 239,279 cases and 5,443 deaths in th...
Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressi...
Resolving the fibrotic niche of human liver cirrhosis at single-cell level
Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a be...
MicroRNA Expression in Zebrafish Embryonic Development
MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by mi...