Publications

Immune Regulation of Cancer

Innate and adaptive immune system cells play a major role in regulating the growth of cancer. Although it is commonly thought that an immune response localized to the tumor will...

CHARMM fluctuating charge force field for proteins: I parameterization and application to bulk organic liquid simulations

Abstract A first‐generation fluctuating charge (FQ) force field to be ultimately applied for protein simulations is presented. The electrostatic model parameters, the atomic har...

Using allele frequencies and geographic subdivision to reconstruct gene trees within a species: molecular variance parsimony.

Abstract We formalize the use of allele frequency and geographic information for the construction of gene trees at the intraspecific level and extend the concept of evolutionary...

Pathogenesis of dengue: challenges to molecular biology

Optical Velocity Patterns, Velocity-Sensitive Neurons, and Space Perception: A Hypothesis

A hypothesis is put forward of how global patterns of optical flow, as discussed by Gibson, Johansson, and others, could be processed by relatively simple physiological mechanis...

The ROSAT Brightest Cluster Sample -- III. Optical spectra of the central cluster galaxies

We present new spectra of dominant galaxies in X-ray selected clusters, which combine with our previously published spectra to form a sample of 256 dominant galaxies in 215 clus...

Information Technology, Incentives, and the Optimal Number of Suppliers

:Buyers are transfonning their relationships with suppliers. For example, instead of playing off dozens or even hundreds of competing suppliers against one another, many finns a...

Critical comments on applying covariance structure modeling

Abstract Covariance structure modeling, also known as structural equation modeling or causal modeling, appears increasingly popular. Such techniques can be used to conduct tests...

Probabilistic and Bottle-Neck Features for LVCSR of Meetings

In recent years, probabilistic features became an integral part of state-of-the-are LVCSR systems. In this work, we are exploring the possibility of obtaining the features direc...

Assessing Allelic Dropout and Genotype Reliability Using Maximum Likelihood

Abstract A growing number of population genetic studies utilize nuclear DNA microsatellite data from museum specimens and noninvasive sources. Genotyping errors are elevated in ...

Low-dose CT of the lungs: preliminary observations.

The potential of low-dose computed tomography (CT) of the lungs was critically evaluated in two patients with normal-appearing lungs and 10 patients with a wide diversity of und...

Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide

ABSTRACT Unlike other class I viral fusion proteins, spike proteins on severe acute respiratory sydrome coronavirus virions are uncleaved. As we and others have demonstrated, in...