Peter J. M. Rottier - Researcher Profile

Publications

3 shown

The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex

Berend‐Jan Bosch , Ruurd van der Zee , Cornelis A. M. de Haan +1 more

ABSTRACT Coronavirus entry is mediated by the viral spike (S) glycoprotein. The 180-kDa oligomeric S protein of the murine coronavirus mouse hepatitis virus strain A59 is posttr...

2003 Journal of Virology 1554 citations

Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide

Berend‐Jan Bosch , Willem Bartelink , Peter J. M. Rottier

ABSTRACT Unlike other class I viral fusion proteins, spike proteins on severe acute respiratory sydrome coronavirus virions are uncleaved. As we and others have demonstrated, in...

2008 Journal of Virology 329 citations

Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

Christine Tait‐Burkard , Monique H. Verheije , Oliver Wicht +7 more

Enveloped viruses need to fuse with a host cell membrane in order to deliver their genome into the host cell. While some viruses fuse with the plasma membrane, many viruses are ...

2014 PLoS Pathogens 409 citations

Researcher Info

h-index: 3
Publications: 3
Citations: 2,292
Institution: Utrecht University

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h-index 3

h-index: Number of publications with at least h citations each.

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