Publications
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Role of autophagy in cancer
Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as...
Statistics notes: Absence of evidence is not evidence of absence
Randomized controlled clinical trials are conducted to determine whether differences of clinical importance exist between selected treatment regimens. When statistical analysis ...
Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025
Abstract Diabetes mellitus is a leading cause of mortality and reduced life expectancy. We aim to estimate the burden of diabetes by type, year, regions, and socioeconomic statu...
PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
The past several years have seen an explosive increase in our understanding of the transcriptional basis of adipose cell differentiation. In particular, a key role has been illu...
Discrete sequential boundaries for clinical trials
Pocock (1977), O'Brien & Fleming (1979) and Slud & Wei (1982) have proposed different methods to construct discrete sequential boundaries for clinical trials. These methods requ...
Maximum likelihood estimation of a migration matrix and effective population sizes in<i>n</i>subpopulations by using a coalescent approach
A maximum likelihood estimator based on the coalescent for unequal migration rates and different subpopulation sizes is developed. The method uses a Markov chain Monte Carlo app...
Pollution and health: a progress update
The Lancet Commission on pollution and health reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk fa...