Gordon Guyatt

How should we measure function in patients with chronic heart and lung disease?

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is incr...

Measuring Health-Related Quality of Life

Clinicians and policymakers are recognizing the importance of measuring health-related quality of life (HRQL) to inform patient management and policy decisions. Self- or intervi...

A methodological framework for assessing health indices

Corticosteroid Therapy for Patients Hospitalized With Community-Acquired Pneumonia

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Going from evidence to recommendations

The GRADE system classifies recommendations made in guidelines as either strong or weak. This article explores the meaning of these descriptions and their implications for patie...

GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables

What is “quality of evidence” and why is it important to clinicians?

Guideline developers use a bewildering variety of systems to rate the quality of the evidence underlying their recommendations. Some are facile, some confused, and others sophis...

Grading quality of evidence and strength of recommendations for diagnostic tests and strategies

Citation: Schünemann, H. J. et al. (2008). 'Grading quality of evidence and strength of recommendations for diagnostic tests and strategies', BMJ 336 (7653), 1106-1110. [Availab...

Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive

<h3>Abstract</h3> Flavin containing monooxygenases (FMOs) are promiscuous enzymes known for metabolizing a wide range of exogenous compounds. In <i>C. elegans</i>, <i>fmo-2</i> ...

Incorporating considerations of resources use into grading recommendations

Guideline panellists have differing opinions on whether resource use should influence decisions on individual patients. As medical care costs rise, resource use considerations b...

Systems for grading the quality of evidence and the strength of recommendations II: Pilot study of a new system

Abstract Background Systems that are used by different organisations to grade the quality of evidence and the strength of recommendations vary. They have different strengths and...

An emerging consensus on grading recommendations?

Clinical practice guidelines have improved in quality over the past 10 years by adhering to a few basic principles, such as conducting thorough systematic reviews of relevant ev...

Symbols were superior to numbers for presenting strength of recommendations to health care consumers: a randomized trial