Bruce M. Spiegelman

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Tumor necrosis factor-α (TNF-α) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-α messenger RNA expression was observed in a...

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha plays an important role ...

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

Insulin resistance is a common problem associated with infections and cancer and, most importantly, is the central component of non-insulin-dependent diabetes mellitus. We have ...

What We Talk About When We Talk About Fat