Rory Collins

Why do we need some large, simple randomized trials?

Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies

Blood pressure, stroke, and coronary heart disease

Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack

Underestimation of Risk Associations Due to Regression Dilution in Long-term Follow-up of Prospective Studies

In prospective studies, disease rates during follow-up are typically analyzed with respect to the values of factors measured during an initial baseline survey. However, because ...

Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease

Most evidence about the effects of blood pressure on the risks of cardiovascular disease derives from two principal sources: prospective non-randomised observational studies of ...

Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.

17,187 patients entering 417 hospitals up to 24 hours (median 5 hours) after the onset of suspected acute myocardial infarction were randomised, with placebo control, between: (...

The Magic of Randomization versus the Myth of Real-World Evidence

Nonrandomized observational analyses have been promoted as alternatives to randomized clinical trials. However, randomization ensures balance between groups, whereas nonrandomiz...

Contrasting male and female trends in tobacco-attributed mortality in China: evidence from successive nationwide prospective cohort studies

Wellcome Trust, MRC, BHF, CR-UK, Kadoorie Charitable Foundation, Chinese MoST and NSFC.

Polychemotherapy for early breast cancer: an overview of the randomised trials