Abstract

Nonrandomized observational analyses have been promoted as alternatives to randomized clinical trials. However, randomization ensures balance between groups, whereas nonrandomized studies are often biased by between-group differences. Efforts to reduce the cost and complexity of clinical trials are preferable to relying on observational studies.

Keywords

Observational studyMedicineRandomizationRandomized controlled trialClinical trialMAGIC (telescope)SurgeryInternal medicine

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Publication Info

Year
2020
Type
article
Volume
382
Issue
7
Pages
674-678
Citations
451
Access
Closed

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Cite This

Rory Collins, Louise Bowman, Martin Landray et al. (2020). The Magic of Randomization versus the Myth of Real-World Evidence. New England Journal of Medicine , 382 (7) , 674-678. https://doi.org/10.1056/nejmsb1901642

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DOI
10.1056/nejmsb1901642