Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow

Abstract

Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow–derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.

Keywords

Bone marrowHaematopoiesisBiologyMyeloidStem cellAntigenIn vivoCell biologyPathologyMyeloid cellsCentral nervous systemImmunologyNeuroscienceMedicineGenetics

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Publication Info

Year: 2000
Type: article
Volume: 290
Issue: 5497
Pages: 1779-1782
Citations: 1829
Access: Closed

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APA Style

                            
                                
                                    Éva Mezey, 
                                
                                    Karen J. Chandross, 
                                
                                    G Harta
                                
                                et al.
                            
                            (2000). 
                            Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow. 
                            Science
                            , 290
                            (5497)
                            , 1779-1782.
                            https://doi.org/10.1126/science.290.5497.1779
                        

Identifiers

DOI: 10.1126/science.290.5497.1779