Abstract
Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.
Keywords
HaematopoiesisStem cellBone marrowBiologyCell biologyAdult stem cellPhenotypeImmunologyMolecular biologyIn vitroEndothelial stem cellGeneticsGene
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Publication Info
- Year
- 1988
- Type
- article
- Volume
- 241
- Issue
- 4861
- Pages
- 58-62
- Citations
- 2814
- Access
- Closed
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Cite This
Gerald J. Spangrude,
Shelly Heimfeld,
Irving L. Weissman
(1988).
Purification and Characterization of Mouse Hematopoietic Stem Cells.
Science
, 241
(4861)
, 58-62.
https://doi.org/10.1126/science.2898810
Identifiers
- DOI
- 10.1126/science.2898810