Abstract

Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.

Keywords

Bone marrowBiologyHaematopoiesisStem cellHepatocyteMesenchymal stem cellLiver regenerationPathologyBone Marrow Stem CellAdult stem cellRegeneration (biology)Cell biologyCancer researchImmunologyEndothelial stem cellMedicineIn vitroBiochemistry

Affiliated Institutions

Related Publications

Publication Info

Year
1999
Type
article
Volume
284
Issue
5417
Pages
1168-1170
Citations
2383
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2383
OpenAlex

Cite This

Byron E. Petersen, William C. Bowen, K. D. Patrene et al. (1999). Bone Marrow as a Potential Source of Hepatic Oval Cells. Science , 284 (5417) , 1168-1170. https://doi.org/10.1126/science.284.5417.1168

Identifiers

DOI
10.1126/science.284.5417.1168