Prevention of HIV-1 Infection with Early Antiretroviral Therapy

2011 New England Journal of Medicine 6,856 citations

Abstract

The early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy. (Funded by the National Institute of Allergy and Infectious Diseases and others; HPTN 052 ClinicalTrials.gov number, NCT00074581.).

Keywords

MedicineHazard ratioSerodiscordantConfidence intervalIncidence (geometry)Internal medicineAntiretroviral therapyTransmission (telecommunications)TuberculosisViral loadRate ratioHuman immunodeficiency virus (HIV)PediatricsImmunologyPathology

MeSH Terms

AdolescentAdultAnti-Retroviral AgentsDisease ProgressionDisease TransmissionInfectiousDrug TherapyCombinationFemaleHIV InfectionsHIV SeropositivityHIV-1HumansKaplan-Meier EstimateMaleProportional Hazards ModelsSexual PartnersSpousesTreatment OutcomeYoung Adult

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Publication Info

Year
2011
Type
article
Volume
365
Issue
6
Pages
493-505
Citations
6856
Access
Closed

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Social media, news, blog, policy document mentions

Citation Metrics

6856
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5644
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Cite This

Myron S. Cohen, Ying Qing Chen, Marybeth McCauley et al. (2011). Prevention of HIV-1 Infection with Early Antiretroviral Therapy. New England Journal of Medicine , 365 (6) , 493-505. https://doi.org/10.1056/nejmoa1105243

Identifiers

DOI
10.1056/nejmoa1105243
PMID
21767103
PMCID
PMC3200068

Data Quality

Data completeness: 86%