Fred Hutch Cancer Center

Integrated analysis of multimodal single-cell data

ezSingleCell is an interactive and easy-to-use application for the analysis of multiple single-cell and spatial omics data types for biologists. It combines the best-performing ...

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Chromosomal Mapping The conformation of the genome in the nucleus and contacts between both proximal and distal loci influence gene expression. In order to map genomic contacts,...

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

Antibody-mediated blockade of PD-L1 induced durable tumor regression (objective response rate of 6 to 17%) and prolonged stabilization of disease (rates of 12 to 41% at 24 weeks...

Dimensionality reduction for visualizing single-cell data using UMAP

Advances in single-cell technologies have enabled high-resolution dissection of tissue composition. Several tools for dimensionality reduction are available to analyze the large...

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak

Outbreak to pandemic In response to global dispersion of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), quarantine measures have been implemented around the world...

A framework for advancing our understanding of cancer-associated fibroblasts

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms