Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival

Abstract

The early initiation of antiretroviral therapy before the CD4+ count fell below two prespecified thresholds significantly improved survival, as compared with deferred therapy.

Keywords

MedicineAntiretroviral therapyAsymptomaticInternal medicineCohortConfidence intervalHuman immunodeficiency virus (HIV)Relative riskSurgeryViral loadImmunology

MeSH Terms

AdultAnti-Retroviral AgentsCD4 Lymphocyte CountConfounding FactorsEpidemiologicDrug Administration ScheduleFemaleHIVHIV InfectionsHumansMaleMiddle AgedProportional Hazards ModelsRNAViralRiskSurvival Analysis

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Publication Info

Year: 2009
Type: article
Volume: 360
Issue: 18
Pages: 1815-1826
Citations: 1103
Access: Closed

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APA Style

                            
                                
                                    Mari M. Kitahata, 
                                
                                    Stephen J. Gange, 
                                
                                    Alison G. Abraham
                                
                                et al.
                            
                            (2009). 
                            Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival. 
                            New England Journal of Medicine
                            , 360
                            (18)
                            , 1815-1826.
                            https://doi.org/10.1056/nejmoa0807252
                        

Identifiers

DOI: 10.1056/nejmoa0807252
PMID: 19339714
PMCID: PMC2854555

Data Quality

Data completeness: 86%