When to Initiate Combined Antiretroviral Therapy to Reduce Mortality and AIDS-Defining Illness in HIV-Infected Persons in Developed Countries

Abstract

Initiation of cART at a threshold CD4 count of 0.500 × 10(9) cells/L increases AIDS-free survival. However, mortality did not vary substantially with the use of CD4 thresholds between 0.300 and 0.500 × 10(9) cells/L.

Keywords

CartMedicineHazard ratioAntiretroviral therapyObservational studyInternal medicineHuman immunodeficiency virus (HIV)Marginal structural modelViral loadProspective cohort studyProportional hazards modelImmunologyConfidence interval

MeSH Terms

Acquired Immunodeficiency SyndromeAnti-Retroviral AgentsCD4 Lymphocyte CountCause of DeathDeveloped CountriesDisease ProgressionDrug Administration ScheduleDrug TherapyCombinationHIV InfectionsHumansObservationProportional Hazards ModelsProspective Studies

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Publication Info

Year: 2011
Type: article
Volume: 154
Issue: 8
Pages: 509-515
Citations: 232
Access: Closed

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Cite This

APA Style

                            
                                
                                    Lauren E. Cain, 
                                
                                    Roger Logan, 
                                
                                    James M. Robins
                                
                                et al.
                            
                            (2011). 
                            When to Initiate Combined Antiretroviral Therapy to Reduce Mortality and AIDS-Defining Illness in HIV-Infected Persons in Developed Countries. 
                            Annals of Internal Medicine
                            , 154
                            (8)
                            , 509-515.
                            https://doi.org/10.7326/0003-4819-154-8-201104190-00001
                        

Identifiers

DOI: 10.7326/0003-4819-154-8-201104190-00001
PMID: 21502648
PMCID: PMC3610527

Data Quality

Data completeness: 81%