Jonathan A C Sterne

RoB 2: a revised tool for assessing risk of bias in randomised trials

Assessment of risk of bias is regarded as an essential component of a systematic review on the effects of an intervention. The most commonly used tool for randomised trials is t...

Sifting the evidence---what's wrong with significance tests? Another comment on the role of statistical methods

The findings of medical research are often met with considerable scepticism, even when they have apparently come from studies with sound methodologies that have been subjected t...

Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials

Funnel plots, and tests for funnel plot asymmetry, have been widely used to examine bias in the results of meta-analyses. Funnel plot asymmetry should not be equated with public...

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Abstract Observational epidemiological studies suffer from many potential biases, from confounding and from reverse causation, and this limits their ability to robustly identify...

Funnel plots for detecting bias in meta-analysis

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

In this prospective meta-analysis of clinical trials of critically ill patients with COVID-19, administration of systemic corticosteroids, compared with usual care or placebo, w...