Michael Houghton

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis (NANBH) agent and screened with serum from a patient ...

An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

A specific assay has been developed for a blood-borne non-A, non-B hepatitis (NANBH) virus in which a polypeptide synthesized in recombinant yeast clones of the hepatitis C viru...

Structure, sequence and expression of the hepatitis delta (δ) viral genome

Biochemical and electron microscopic data indicate that the human hepatitis delta viral agent contains a covalently closed circular and single-stranded RNA genome that has certa...

A single antigenomic open reading frame of the hepatitis delta virus encodes the epitope(s) of both hepatitis delta antigen polypeptides p24 delta and p27 delta

On the basis of the complete nucleotide sequence of the single-stranded, covalently closed circular hepatitis delta virus RNA genome (K.-S. Wang, Q.-L. Choo, A. J. Weiner, J.-H....

Structure, sequence and expression of the hepatitis delta (δ) viral genome

The absence of introns within a human fibroblast interferon gene

Experiments in which immobilised restriction fragments of genomic DNA were hybridised with a cloned human fibroblast interferon cDNA indicate that the homologous chromosomal gen...

Hepatitis delta (δ) cDNA clones: Undetectable hybridization to nucleic acids from infectious non‐A, non‐B hepatitis materials and hepatitis B DNA

Abstract Hepatitis Delta(δ) cDNA clones were hybridized to RNA extracted from livers of chimpanzees infected with the blood‐borne Non‐A, Non‐B hepatitis (NANBH) agent(s) and to ...