Abstract

Biochemical and electron microscopic data indicate that the human hepatitis delta viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with viroid-like agents from plants. The sequence of the viral genome (1,678 nucleotides) has been determined and an open reading frame within the complementary strand has been shown to encode an antigen that binds specifically to antisera from patients with chronic hepatitis delta viral infections.

Keywords

ViroidVirologyGenomeBiologyRNAOpen reading frameSequence (biology)Viral hepatitisNucleic acid sequenceNucleotideHEPATITIS DELTAENCODEGeneticsComputational biologyPeptide sequenceDNAGene

MeSH Terms

Base SequenceCloningMolecularDNAGene Expression RegulationGenesGenesViralHepatitis B AntigensHepatitis Delta VirusHepatitis delta AntigensRNAViral

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Publication Info

Year
1986
Type
article
Volume
323
Issue
6088
Pages
508-514
Citations
686
Access
Closed

External Links

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Cite This

Kang-Sheng Wang, Qui‐Lim Choo, Amy J. Weiner et al. (1986). Structure, sequence and expression of the hepatitis delta (δ) viral genome. Nature , 323 (6088) , 508-514. https://doi.org/10.1038/323508a0

Identifiers

DOI
10.1038/323508a0
PMID
3762705

Data Quality

Data completeness: 86%