Abstract

Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by T H 1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.

Keywords

BiologyGeneHomology (biology)CytokineVirusVirologyOpen reading frameEpstein–Barr virusGenomeMolecular biologyGeneticsPeptide sequence

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Publication Info

Year
1990
Type
article
Volume
248
Issue
4960
Pages
1230-1234
Citations
1147
Access
Closed

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Kevin W. Moore, Paulo Vieira, David Fiorentino et al. (1990). Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI. Science , 248 (4960) , 1230-1234. https://doi.org/10.1126/science.2161559

Identifiers

DOI
10.1126/science.2161559