Joseph L. Goldstein

Selective versus Total Insulin Resistance: A Pathogenic Paradox

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia.

This report describes the features of developing atherosclerosis in the Watanabe heritable hyperlipidemic (WHHL) rabbit, an animal model of human familial hypercholesterolemia. ...

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

Resident mouse peritoneal macrophages were shown to take up and degrade acetylated 125 I-labeled low density lipoprotein ( 125 I-acetyl-LDL) in vitro at rates that were 20-fold ...

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerou...

Receptor-Mediated Control of Cholesterol Metabolism

Regulation of Plasma Cholesterol by Lipoprotein Receptors

The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Cruci...