SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Keywords

Sterol regulatory element-binding proteinBiologyLeucine zipperTranscription factorBiochemistrySterolProteolysisCell biologyATF3Endoplasmic reticulumTranscription (linguistics)ProteasesMolecular biologyGeneGene expressionPromoterCholesterolEnzyme

Affiliated Institutions

Related Publications

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

Kyosuke Haze , Hiderou Yoshida , Hideki Yanagi +2 more

The unfolded protein response (UPR) controls the levels of molecular chaperones and enzymes involved in protein folding in the endoplasmic reticulum (ER). We recently isolated A...

1999 Molecular Biology of the Cell 1997 citations

<b>Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic‐leucine zipper motif is required for the unfolded protein‐response pathway</b>

Kazutoshi Mori , Tetsushi Kawahara , Hiderou Yoshida +2 more

Background : Accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the transcriptional induction of molecular chaperones and folding enzymes localized in ...

1996 Genes to Cells 361 citations

The HAT4 gene of Arabidopsis encodes a developmental regulator.

Mark Schena , Alan Lloyd , Ronald W. Davis

The HAT4 gene from the plant Arabidopsis thaliana encodes a homeo domain protein that contains a leucine zipper motif. Homeo domain-leucine zipper (HD-Zip) proteins have not bee...

1993 Genes & Development 134 citations

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

Philippe Delerive , Karolien De Bosscher , Sandrine Besnard +7 more

Interleukin-6 (IL-6) is a pleiotropic cytokine, whose plasma levels are elevated in inflammatory diseases such as atherosclerosis. We have previously reported that peroxisome pr...

1999 Journal of Biological Chemistry 1062 citations

The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization

David M. Harlan , Jonathan M. Graff , Deborah J. Stumpo +4 more

The expression of a major cellular substrate for protein kinase C, the MARCKS protein, is regulated in a cell-, tissue-, and developmental stage-specific fashion; in addition, t...

1991 Journal of Biological Chemistry 84 citations

Publication Info

Year: 1994
Type: article
Volume: 77
Issue: 1
Pages: 53-62
Citations: 995
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

995

OpenAlex

Cite This

APA Style

                            
                                
                                    Xiaodong Wang, 
                                
                                    Ryuichiro Sato, 
                                
                                    Michael S. Brown
                                
                                et al.
                            
                            (1994). 
                            SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. 
                            Cell
                            , 77
                            (1)
                            , 53-62.
                            https://doi.org/10.1016/0092-8674(94)90234-8
                        

Identifiers

DOI: 10.1016/0092-8674(94)90234-8