Abstract
The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis in man.
Keywords
ReceptorPlasma lipoproteinCholesterolLipoproteinLDL receptorChemistryInternal medicineEndocrinologyBiochemistryBiologyMedicine
Affiliated Institutions
Related Publications
Receptor-mediated Catabolism of Low Density Lipoprotein in Man. QUANTITATION USING GLUCOSYLATED LOW DENSITY LIPOPROTEIN
Low density lipoprotein (LDL) catabolism occurs by LDL receptor-dependent and LDL receptor-independent pathways. We have shown previously that nonenzymatic glucosylation of LDL ...
Atherosclerosis — An Inflammatory Disease
Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the p...
Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits.
Low density lipoprotein (LDL) catabolism was studied using WHHL rabbits, an inbred strain deficient in LDL receptor activity and, thus, an animal model for homozygous familial h...
Three-dimensional structure of a cysteine-rich repeat from the low-density lipoprotein receptor.
The low-density lipoprotein (LDL) receptor plays a central role in mammalian cholesterol metabolism, clearing lipoproteins which bear apolipoproteins E and B-100 from plasma. Mu...
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
Resident mouse peritoneal macrophages were shown to take up and degrade acetylated 125 I-labeled low density lipoprotein ( 125 I-acetyl-LDL) in vitro at rates that were 20-fold ...
Publication Info
- Year
- 1981
- Type
- article
- Volume
- 212
- Issue
- 4495
- Pages
- 628-635
- Citations
- 950
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
950
OpenAlex
Cite This
Michael S. Brown,
Petri T. Kovanen,
Joseph L. Goldstein
(1981).
Regulation of Plasma Cholesterol by Lipoprotein Receptors.
Science
, 212
(4495)
, 628-635.
https://doi.org/10.1126/science.6261329
Identifiers
- DOI
- 10.1126/science.6261329