Hiroshi Maeda

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

We previously found that a polymer conjugated to the anticancer protein neocarzinostatin, named smancs, accumulated more in tumor tissues than did neocarzinostatin. To determine...

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo

ADVERTISEMENT RETURN TO ISSUEArticleNEXTConjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivoHiroshi Maeda, Len W. Seymour, and Yoichi ...

Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues

The objective of this study was to investigate the molecular weight (MW) and time‐dependence of the phenomenon termed “the enhanced permeability and retention”(EPR) effect in so...

Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report

A clinical evaluation of arterial infusion of high-molecular-weight antitumor agent SMANCS dissolved in lipid lymphographic agent (thiodol) in 44 patients with mostly unresectab...

Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor

A newly discovered nitric oxide radical scavenger, an imidazolineoxyl N ‐oxide derivative, was used to investigate the role of nitric oxide radical (*NO) in the vascular permeab...

Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium

A new type of anticancer agent with an amphiphilic nature, poly(styrene-co-maleic acid)-conjugated neocarzinostatin (Smancs), was dissolved in lipid contrast medium Lipiodol (Sm...

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Most solid tumors possess unique pathophysiological characteristics that are not observed in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature,...

Tumoritropic and lymphotropic principles of macromolecular drugs.

The advantages and disadvantages of macromolecular drugs, particularly on synthetic polymer-protein conjugates, are described in this article. Improvements in protein drugs, aft...

Polymer Conjugation to Cu,Zn-SOD and Suppression of Hydroxyl Radical Generation on Exposure to H2O2: Improved Stability of SOD in Vitro and in Vivo

Highly reactive hydroxyl radical (OH) is generated during reaction of Cu,Zn-SOD (SOD) 1 with H 2 0 2 , its own enzymatic reaction product (SOD plus 0;-). During inactivation of ...

Conjugation of copper-zinc superoxide dismutase with succinylated gelatin: Pharmacological activity and cell-lubricating function

Superoxide dismutase (SOD) and succinylated gelatin (succinyl gelatin) were conjugated to improve in vivo pharmacological activity of SOD. Lysyl residues of human recombinant Cu...

Role of Nitric Oxide and Superoxide in Acute Cardiac Allograft Rejection in Rats

The role of NO and superoxide (O(2)(-)) in tissue injury during cardiac allograft rejection was investigated by using a rat ex vivo organ perfusion system. Excessive NO producti...