Abstract

A clinical evaluation of arterial infusion of high-molecular-weight antitumor agent SMANCS dissolved in lipid lymphographic agent (thiodol) in 44 patients with mostly unresectable hepatoma is described. The treatment regimen demonstrated significant merits both therapeutically and diagnostically. Marked antitumor effects were shown in the decreased serum alpha-fetoprotein levels (86% of cases) and tumor size (95% of cases), and in survival period and histological findings. Furthermore, there was increased diagnostic sensitivity using CT scan, plain X-rays or ultrasound. The procedure of selective arterial administration of 3-4 mg of SMANCS in 3-4 ml of ethiodol per dose was simple to perform and was required only once every 3-4 weeks. Both ethiodol and the drug accumulated more selectively in tumor than in any other tissues and their activity remained for more than 3 weeks. Only minimal side-effects were associated with SMANCS and ethiodol during this study.

Keywords

MedicineChemotherapyBody weightRegimenInternal medicine

MeSH Terms

AdultAgedAntibioticsAntineoplasticCarcinomaHepatocellularDrug CombinationsEthiodized OilFemaleHumansInjectionsIntra-ArterialLiver NeoplasmsMaleMaleic AnhydridesMiddle AgedPolystyrenesPrognosisTomographyX-Ray ComputedZinostatin

Affiliated Institutions

Related Publications

Publication Info

Year
1983
Type
article
Volume
19
Issue
8
Pages
1053-1065
Citations
342
Access
Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

342
OpenAlex
13
Influential
269
CrossRef

Cite This

Toshimitsu Konno, Hiroshi Maeda, Ken Iwai et al. (1983). Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report. European Journal of Cancer and Clinical Oncology , 19 (8) , 1053-1065. https://doi.org/10.1016/0277-5379(83)90028-7

Identifiers

DOI
10.1016/0277-5379(83)90028-7
PMID
6311559

Data Quality

Data completeness: 86%