Keywords
Affiliated Institutions
Related Publications
Tumoritropic and lymphotropic principles of macromolecular drugs.
The advantages and disadvantages of macromolecular drugs, particularly on synthetic polymer-protein conjugates, are described in this article. Improvements in protein drugs, aft...
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Most solid tumors possess unique pathophysiological characteristics that are not observed in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature,...
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
We previously found that a polymer conjugated to the anticancer protein neocarzinostatin, named smancs, accumulated more in tumor tissues than did neocarzinostatin. To determine...
Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo
ADVERTISEMENT RETURN TO ISSUEArticleNEXTConjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivoHiroshi Maeda, Len W. Seymour, and Yoichi ...
Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma
Doxorubicin (5 mg kg-1) was administered intravenously to C57 mice bearing subcutaneous B16F10 melanomas, distributing into the tumour with an area under the concentration-time ...
Publication Info
- Year
- 1991
- Type
- article
- Volume
- 6
- Issue
- 2
- Pages
- 181-202
- Citations
- 211
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1016/0169-409x(91)90040-j