We Need Both Exploratory and Confirmatory
Abstract We often forget how science and engineering function. Ideas come from previous exploration more often than from lightning strokes. Important questions can demand the mo...
Publications
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152 publications
Quantifying prion disease penetrance using large population control cohorts
Large genomic reference data sets reveal a spectrum of pathogenicity in the prion protein gene and provide genetic validation for a therapeutic strategy in prion disease.
Finite-Mixture Structural Equation Models for Response-Based Segmentation and Unobserved Heterogeneity
Two endemic problems face researchers in the social sciences (e.g., Marketing, Economics, Psychology, and Finance): unobserved heterogeneity and measurement error in data. Struc...
Performance-Based Selection of Likelihood Models for Phylogeny Estimation
Phylogenetic estimation has largely come to rely on explicitly model-based methods. This approach requires that a model be chosen and that that choice be justified. To date, jus...
Information Acquisition Behavior in Brand Choice Situations
A behavioral process methodology was utilized to examine the amount and type of information acquired by consumers from package panels prior to making purchase decisions. Consume...
<i>nodal</i> expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
ABSTRACT Mouse nodal, a member of the TGFβ family of secreted growth factors is essential for gastrulation. We recently generated a nodallacZ reporter allele by homologous recom...
Organizing Successful Co-Marketing Alliances
Co-marketing alliances between firms afford fresh opportunity for strategic advantage. Data from 98 alliances show that gains in effectiveness can be obtained by reducing power ...
Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease
Accumulation of amyloid-beta (Abeta) is one of the earliest molecular events in Alzheimer disease (AD), whereas tau pathology is thought to be a later downstream event. It is no...
Gaussian Process Priors with Uncertain Inputs Application to Multiple-Step Ahead Time Series Forecasting
We consider the problem of multi-step ahead prediction in time series analysis using the non-parametric Gaussian process model. k-step ahead forecasting of a discrete-time non-l...
Calibrated Tree Priors for Relaxed Phylogenetics and Divergence Time Estimation
The use of fossil evidence to calibrate divergence time estimation has a long history. More recently, Bayesian Markov chain Monte Carlo has become the dominant method of diverge...
New chronology for the late Paleocene thermal maximum and its environmental implications
Research Article| October 01, 2000 New chronology for the late Paleocene thermal maximum and its environmental implications U. Röhl; U. Röhl 1Department of Geosciences, Bremen U...
Roles of <i>wingless</i> in patterning the larval epidermis of <i>Drosophila</i>
ABSTRACT The larval epidermis of Drosophila shows a stereotyped segmentally repeating pattern of cuticular structures. Mutants deficient for the wingless gene product show highl...