Publications
Explore 124 academic publications
The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition
Snail family genes encode DNA binding zinc finger proteins that act as transcriptional repressors. Mouse embryos deficient for the Snail (Sna) gene exhibit defects in the format...
Interleukin 6 Is Required for the Development of Collagen-induced Arthritis
Interleukin-6 (IL-6) is overproduced in the joints of patients with rheumatoid arthritis (RA) and, based on its multiple stimulatory effects on cells of the immune system and on...
Predicting a Human Gut Microbiota’s Response to Diet in Gnotobiotic Mice
Model microbial communities in mouse guts respond quickly and predictably to dietary shifts.
Nexus: An Extensible File Format for Systematic Information
NEXUS is a file format designed to contain systematic data for use by computer programs. The goals of the format are to allow future expansion, to include diverse kinds of infor...
Mouse Embryonic Stem Cells and Reporter Constructs to Detect Developmentally Regulated Genes
A strategy was devised for identifying regions of the mouse genome that are transcriptionally active in a temporally and spatially restricted manner during development. The appr...
Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs
Abstract Background Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion in...
<i>nodal</i> expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
ABSTRACT Mouse nodal, a member of the TGFβ family of secreted growth factors is essential for gastrulation. We recently generated a nodallacZ reporter allele by homologous recom...
Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis.
The interaction of homologous and heterologous albumin-gold complex (Alb-Au) with capillary endothelium was investigated in the mouse lung, heart, and diaphragm. Perfusion of th...
Development of a Companion Diagnostic PD-L1 Immunohistochemistry Assay for Pembrolizumab Therapy in Non–Small-cell Lung Cancer
A companion diagnostic assay was codeveloped by Dako for pembrolizumab non–small-cell lung cancer clinical trials to detect PD-L1 expression by immunohistochemistry (IHC). This ...
Systematic Assembly of a Full-Length Infectious cDNA of Mouse Hepatitis Virus Strain A59
ABSTRACT A novel method was developed to assemble a full-length infectious cDNA of the group II coronavirus mouse hepatitis virus strain A59 (MHV-A59). Seven contiguous cDNA clo...