Genetic Dissection of Transcriptional Regulation in Budding Yeast
To begin to understand the genetic architecture of natural variation in gene expression, we carried out genetic linkage analysis of genomewide expression patterns in a cross bet...
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621 publications
An Eulerian path approach to DNA fragment assembly
For the last 20 years, fragment assembly in DNA sequencing followed the “overlap–layout–consensus” paradigm that is used in all currently available assembly tools. Although this...
Surface Enhanced Raman Spectroscopy of Individual Rhodamine 6G Molecules on Large Ag Nanocrystals
To explore the relationship between local electromagnetic field enhancement and the large SERS (surface enhanced Raman scattering) enhancement that enables the observation of si...
Eigenvalues and Condition Numbers of Random Matrices
Given a random matrix, what condition number should be expected? This paper presents a proof that for real or complex $n \times n$ matrices with elements from a standard normal ...
Symmetry Breaking in Non-Abelian Gauge Theories
According to the Goldstone theorem, any manifestly covariant broken-symmetry theory must exhibit massless particles. However, it is known from previous work that such particles ...
Error filtering, pair assembly and error correction for next-generation sequencing reads
Abstract Motivation: Next-generation sequencing produces vast amounts of data with errors that are difficult to distinguish from true biological variation when coverage is low. ...
Allele-specific copy number analysis of tumors
We present an allele-specific copy number analysis of the in vivo breast cancer genome. We describe a unique bioinformatics approach, ASCAT (allele-specific copy number analysis...
SARS: Systematic Review of Treatment Effects
Despite an extensive literature reporting on SARS treatments, it was not possible to determine whether treatments benefited patients during the SARS outbreak. Some may have been...
Cluster-Sample Methods in Applied Econometrics
Inference methods that recognize the clustering of individual observations have been available for more than 25 years. Brent Moulton (1990) caught the attention of economists wh...
An Investigation into the Determinants of Customer Satisfaction
The authors investigate whether it is necessary to include disconfirmation as an intervening variable affecting satisfaction as is commonly argued, or whether the effect of disc...