Haixu Tang

An Eulerian path approach to DNA fragment assembly

For the last 20 years, fragment assembly in DNA sequencing followed the “overlap–layout–consensus” paradigm that is used in all currently available assembly tools. Although this...

Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution

Fragment assembly with short reads

Abstract Motivation: Current DNA sequencing technology produces reads of about 500–750 bp, with typical coverage under 10×. New sequencing technologies are emerging that produce...

Whole-Genome Sequencing and Assembly with High-Throughput, Short-Read Technologies

While recently developed short-read sequencing technologies may dramatically reduce the sequencing cost and eventually achieve the $1000 goal for re-sequencing, their limitation...