Central nervous system control of food intake
New information regarding neuronal circuits that control food intake and their hormonal regulation has extended our understanding of energy homeostasis, the process whereby ener...
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2,741 publications
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Predicting responses to immunotherapy Colon cancers with loss-of-function mutations in the mismatch repair (MMR) pathway have favorable responses to PD-1 blockade immunotherapy....
Protein Misfolding, Functional Amyloid, and Human Disease
Peptides or proteins convert under some conditions from their soluble forms into highly ordered fibrillar aggregates. Such transitions can give rise to pathological conditions r...
First Case of 2019 Novel Coronavirus in the United States
An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCo...
The information capacity of the human motor system in controlling the amplitude of movement.
Information theory has recently been employed to specify more precisely than has hitherto been possible man's capacity in certain sensory, perceptual, and perceptual-motor funct...
Reciprocal Relations in Irreversible Processes. I.
Examples of coupled irreversible processes like the thermoelectric phenomena, the transference phenomena in electrolytes and heat conduction in an anisotropic medium are conside...
Core capabilities and core rigidities: A paradox in managing new product development
This paper examines the nature of the core capabilities of a firm, focusing in particular on their interaction with new product and process development projects. Two new concept...
Crystal Statistics. I. A Two-Dimensional Model with an Order-Disorder Transition
The partition function of a two-dimensional "ferromagnetic" with scalar "spins" (Ising model) is computed rigorously for the case of vanishing field. The eigenwert problem invol...
Qualitative Quality: Eight “Big-Tent” Criteria for Excellent Qualitative Research
This article presents a model for quality in qualitative research that is uniquely expansive, yet flexible, in that it makes distinctions among qualitative research’s means (met...
voom: precision weights unlock linear model analysis tools for RNA-seq read counts
Abstract New normal linear modeling strategies are presented for analyzing read counts from RNA-seq experiments. The voom method estimates the mean-variance relationship of the ...
Justice and the Politics of Difference
book challenges the prevailing philosophical reduction of social justice to distributive justice. It critically analyzes basic concepts underlying most theories of justice, incl...
The governance of global value chains
Abstract This article builds a theoretical framework to help explain governance patterns in global value chains. It draws on three streams of literature – transaction costs econ...