First Case of 2019 Novel Coronavirus in the United States

Michelle Holshue , Chas DeBolt , Scott Lindquist , Michelle Holshue , Chas DeBolt , Scott Lindquist , Kathy Lofy , John Wiesman , Hollianne Bruce , Christopher Spitters , Keith M. Marzilli Ericson , Sara Wilkerson , Ahmet Tural , George Diaz , Amanda Cohn , LeAnne M. Fox , Anita Patel , Susan I. Gerber , Lindsay Kim , Suxiang Tong , Xiaoyan Lu , Steve Lindstrom , Mark A. Pallansch , William C. Weldon , Holly M. Biggs , Timothy M. Uyeki , Satish K. Pillai
2020 New England Journal of Medicine 6,319 citations

Abstract

An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient's initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection.

Keywords

Coronavirus disease 2019 (COVID-19)CoronavirusOutbreakPublic healthPneumoniaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MedicineChina2019-20 coronavirus outbreakPresentation (obstetrics)Intensive care medicineFamily medicineEnvironmental healthPolitical scienceDiseaseVirologyInfectious disease (medical specialty)PathologySurgeryInternal medicine

MeSH Terms

AdultBetacoronavirusBlood Chemical AnalysisCOVID-19COVID-19 TestingChinaClinical Laboratory TechniquesCoronavirus InfectionsDisease ProgressionGenomeViralHumansLungMalePneumoniaViralRadiographyThoracicSARS-CoV-2Sequence AnalysisDNATravelUnited States

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Publication Info

Year
2020
Type
article
Volume
382
Issue
10
Pages
929-936
Citations
6319
Access
Closed

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Cite This

Michelle Holshue, Chas DeBolt, Scott Lindquist et al. (2020). First Case of 2019 Novel Coronavirus in the United States. New England Journal of Medicine , 382 (10) , 929-936. https://doi.org/10.1056/nejmoa2001191

Identifiers

DOI
10.1056/nejmoa2001191
PMID
32004427
PMCID
PMC7092802

Data Quality

Data completeness: 86%