Daniel Porte

Central nervous system control of food intake

New information regarding neuronal circuits that control food intake and their hormonal regulation has extended our understanding of energy homeostasis, the process whereby ener...

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

The adipocyte hormone, leptin (OB protein), is proposed to be an "adiposity signal" that acts in the brain to lower food intake and adiposity. As plasma leptin levels are elevat...

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

The level of insulin after an overnight fast (basal) in 37 obese and nonobese male subjects with normal and abnormal carbohydrate tolerance was directly related to the increase ...

Evidence That Plasma Leptin and Insulin Levels are Associated With Body Adiposity Via Different Mechanisms

OBJECTIVE Like insulin, the adipocyte hormone, leptin, circulates at levels proportionate to body adiposity. Because insulin may regulate leptin secretion, we sought to determin...