Abstract

Stem cells are found in various organs where they participate in tissue homeostasis by replacing differentiated cells lost to physiological turnover or injury. An investigation was performed to determine whether stem cells are restricted to produce specific cell types, namely, those from the tissue in which they reside. After transplantation into irradiated hosts, genetically labeled neural stem cells were found to produce a variety of blood cell types including myeloid and lymphoid cells as well as early hematopoietic cells. Thus, neural stem cells appear to have a wider differentiation potential than previously thought.

Keywords

Stem cellHaematopoiesisNeural stem cellBiologyAdult stem cellCell biologyClinical uses of mesenchymal stem cellsPrecursor cellImmunologyCellEndothelial stem cellIn vitroGenetics

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Publication Info

Year
1999
Type
article
Volume
283
Issue
5401
Pages
534-537
Citations
1422
Access
Closed

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Cite This

Christopher R.R. Bjornson, Rodney L. Rietze, Brent A. Reynolds et al. (1999). Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo. Science , 283 (5401) , 534-537. https://doi.org/10.1126/science.283.5401.534

Identifiers

DOI
10.1126/science.283.5401.534