Abstract

The committed stem and progenitor cells have been recently isolated from various adult tissues, including hematopoietic stem cell, neural stem cell, mesenchymal stem cell and endothelial progenitor cell. These adult stem cells have several advantages as compared with embryonic stem cells as their practical therapeutic application for tissue regeneration. In this review, we discuss the promising gene therapy application of adult stem and progenitor cells in terms of modifying stem cell potency, altering organ property, accelerating regeneration and forming expressional organization.

Keywords

Stem cellBiologyProgenitor cellEndothelial stem cellAdult stem cellEmbryonic stem cellGenetic enhancementCell biologyMesenchymal stem cellRegeneration (biology)Stem-cell therapyStem cell transplantation for articular cartilage repairHaematopoiesisInduced stem cellsClinical uses of mesenchymal stem cellsImmunologyGeneticsGeneIn vitro

MeSH Terms

AdultAnimalsDependovirusGene Transfer TechniquesGenetic TherapyGenetic VectorsHumansLentivirusRegenerationRetroviridaeStem Cell TransplantationWounds and Injuries

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Publication Info

Year
2000
Type
review
Volume
7
Issue
6
Pages
451-457
Citations
194
Access
Closed

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Cite This

Takayuki Asahara, Christoph Kalka, Jeffrey M. Isner (2000). Stem cell therapy and gene transfer for regeneration. Gene Therapy , 7 (6) , 451-457. https://doi.org/10.1038/sj.gt.3301142

Identifiers

DOI
10.1038/sj.gt.3301142
PMID
10757017

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Data completeness: 86%