Abstract
Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned from a mouse placenta cDNA library. All three display strong homology in membrane-spanning domains M7 and M8 to the originally cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting heterogeneity of IP3 action within a single cell.
Keywords
Inositol trisphosphate receptorInositolReceptorBiologyComplementary DNACloning (programming)CytoplasmCell biologyGeneBiochemistry
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Publication Info
- Year
- 1992
- Type
- article
- Volume
- 89
- Issue
- 10
- Pages
- 4265-4269
- Citations
- 254
- Access
- Closed
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Cite This
C A Ross,
Sonye K. Danoff,
Michael J. Schell
et al.
(1992).
Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues..
Proceedings of the National Academy of Sciences
, 89
(10)
, 4265-4269.
https://doi.org/10.1073/pnas.89.10.4265
Identifiers
- DOI
- 10.1073/pnas.89.10.4265