Abstract
Abstract The second messenger function of inositol 1,4,5‐ trisphosphate (Ins P 3 ) is now well‐defined – it mobilizes Ca 2+ from intracellular stores so that cytosolic Ca 2+ increases. However, the function of inositol 1,3,4,5‐ tetrakisphosphate (Ins P 4 ) has proved much more difficult to fathom, as it has been reported to exert a wide variety of effects in a collection of experimental systems. In this review, a proposed molecular mechanism for Ins P 4 actions is discussed; it is suggested that Ins P 4 is the second messenger that controls Ca 2+ entry into cells, and that it does so by binding to a receptor which itself interacts, directly or Indirectly, with the receptor for Ins P 3 It is proposed that this is Ins P 4 's true physiological function, but the mechanism by which it exerts this function has led to confusing data concerning its action, and also to some misconceptions about how inositol phosphates control Ca 2+ entry.
Keywords
Second messenger systemInositolResolution (logic)BiologyComputational biologyChemistryBiochemistryComputer scienceArtificial intelligenceSignal transductionReceptor
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Publication Info
- Year
- 1991
- Type
- review
- Volume
- 13
- Issue
- 8
- Pages
- 419-427
- Citations
- 119
- Access
- Closed
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Cite This
Robin F. Irvine
(1991).
Inositol tetrakisphosphate as a second messenger: Confusions, contradictions, and a potential resolution.
BioEssays
, 13
(8)
, 419-427.
https://doi.org/10.1002/bies.950130810
Identifiers
- DOI
- 10.1002/bies.950130810