Robin F. Irvine

Inositol phosphates and cell signalling

‘Quanta’ Ca²⁺ release and the control of Ca²⁺ entry by inositol phosphates ‐ a possible mechanism

The release of Ca 2+ from intracellular stores by sub‐optimal doses of inositol trisphosphate has been shown to be dose‐related (‘quantal’), and a simple model is proposed here ...

Inositol tetrakisphosphate as a second messenger: Confusions, contradictions, and a potential resolution

Abstract The second messenger function of inositol 1,4,5‐ trisphosphate (Ins P 3 ) is now well‐defined – it mobilizes Ca 2+ from intracellular stores so that cytosolic Ca 2+ inc...

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

The formation of inositol phosphates in response to agonists was studied in brain slices, parotid gland fragments and in the insect salivary gland. The tissues were first incuba...