Maria Chiara Maiuri

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Self-eating and self-killing: crosstalk between autophagy and apoptosis

Apoptotic cell death is mediated by molecular pathways that culminate in the activation of a family of cysteine proteases, known as the caspases, which orchestrate the dismantli...

Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1

The anti-apoptotic proteins Bcl-2 and Bcl-X(L) bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we demonstrate that this interaction involves a BH3 domain wi...

Regulation of autophagy by the inositol trisphosphate receptor

The reduction of intracellular 1,4,5-inositol trisphosphate (IP(3)) levels stimulates autophagy, whereas the enhancement of IP(3) levels inhibits autophagy induced by nutrient d...

Cell death modalities: classification and pathophysiological implications