Self-eating and self-killing: crosstalk between autophagy and apoptosis

Abstract

Apoptotic cell death is mediated by molecular pathways that culminate in the activation of a family of cysteine proteases, known as the caspases, which orchestrate the dismantling and clearance of the dying cell. However, mounting evidence indicates that a cell that has been treated with an apoptotic inducer can also initiate a suicide programme that does not rely on caspase activation. Here, we present recent findings and discuss the physiological relevance of caspase-independent cell death.

Keywords

AutophagyCrosstalkApoptosisCell biologyProgrammed cell deathBiologyCellular stress responseCellGeneticsFight-or-flight responseGenePhysics

MeSH Terms

AnimalsApoptosisCaspasesDNA DamageHumansMiceMitochondria

Affiliated Institutions

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Publication Info

Year: 2007
Type: review
Volume: 8
Issue: 9
Pages: 741-752
Citations: 3586
Access: Closed

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APA Style

                            
                                
                                    Maria Chiara Maiuri, 
                                
                                    Einat Zalckvar, 
                                
                                    Adi Kimchi
                                
                                et al.
                            
                            (2007). 
                            Self-eating and self-killing: crosstalk between autophagy and apoptosis. 
                            Nature Reviews Molecular Cell Biology
                            , 8
                            (9)
                            , 741-752.
                            https://doi.org/10.1038/nrm2239
                        

Identifiers

DOI: 10.1038/nrm2239
PMID: 15714200

Data Quality

Data completeness: 86%