The InterPro protein families and domains database: 20 years on

Abstract

Abstract The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. InterProScan is the underlying software that allows protein and nucleic acid sequences to be searched against InterPro's signatures. Signatures are predictive models which describe protein families, domains or sites, and are provided by multiple databases. InterPro combines signatures representing equivalent families, domains or sites, and provides additional information such as descriptions, literature references and Gene Ontology (GO) terms, to produce a comprehensive resource for protein classification. Founded in 1999, InterPro has become one of the most widely used resources for protein family annotation. Here, we report the status of InterPro (version 81.0) in its 20th year of operation, and its associated software, including updates to database content, the release of a new website and REST API, and performance improvements in InterProScan.

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Affiliated Institutions

• Institute of Structural and Molecular Biology GB
• European Bioinformatics Institute GB
• SIB Swiss Institute of Bioinformatics CH
• European Molecular Biology Laboratory DE
• Biobyte Solutions (Germany) DE
• University of Padua IT
• Medical Research Council GB
• University College London GB
• Georgetown University US
• MRC Laboratory of Molecular Biology GB
• University of Southern California US
• Georgetown University Medical Center US
• National Center for Biotechnology Information US
• National Institutes of Health US

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