Abstract
The Catalytic Site Atlas (CSA) provides catalytic residue annotation for enzymes in the Protein Data Bank. It is available online at http://www.ebi.ac.uk/thornton-srv/databases/CSA. The database consists of two types of annotated site: an original hand-annotated set containing information extracted from the primary literature, using defined criteria to assign catalytic residues, and an additional homologous set, containing annotations inferred by PSI-BLAST and sequence alignment to one of the original set. The CSA can be queried via Swiss-Prot identifier and EC number, as well as by PDB code. CSA Version 1.0 contains 177 original hand- annotated entries and 2608 homologous entries, and covers approximately 30% of all EC numbers found in PDB. The CSA will be updated on a monthly basis to include homologous sites found in new PDBs, and new hand-annotated enzymes as and when their annotation is completed.
Keywords
Protein Data Bank (RCSB PDB)AnnotationBiologyIdentifierProtein superfamilyComputational biologyProtein Data BankSequence alignmentDatabaseEnzymeMultiple sequence alignmentSet (abstract data type)BioinformaticsInformation retrievalBiochemistryComputer sciencePeptide sequenceProtein structureProgramming languageGene
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Publication Info
- Year
- 2003
- Type
- article
- Volume
- 32
- Issue
- 90001
- Pages
- 129D-133
- Citations
- 608
- Access
- Closed
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Cite This
C. T. Porter
(2003).
The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data.
Nucleic Acids Research
, 32
(90001)
, 129D-133.
https://doi.org/10.1093/nar/gkh028
Identifiers
- DOI
- 10.1093/nar/gkh028