Medical Research Council

Introduction to Meta‐Analysis

The MR-Base platform supports systematic causal inference across the human phenome

Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SM...

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemic...

WinBUGS - A Bayesian modelling framework: Concepts, structure, and extensibility

A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance

Complex interventions are commonly used in the health and social care services, public health practice, and other areas of social and economic policy that have consequences for ...

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the r...

Theoretical studies of enzymic reactions: Dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in obs...

Drug repurposing: progress, challenges and recommendations

Gctf: Real-time CTF determination and correction

Accurate estimation of the contrast transfer function (CTF) is critical for a near-atomic resolution cryo electron microscopy (cryoEM) reconstruction. Here, a GPU-accelerated co...