Abstract

Abstract Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation of its main effector, hypoxia-inducible factor-1 (HIF-1), are common features of advanced cancers. In addition to the impact on tumour cell biology, the influence that hypoxia exerts on the surrounding cells represents a critical step in the tumorigenic process. Hypoxia indeed enables a number of events in the tumour microenvironment that lead to the expansion of aggressive clones from heterogeneous tumour cells and promote a lethal phenotype. In this article, we review the most relevant findings describing the influence of hypoxia and the contribution of HIF activation on the major components of the tumour microenvironment, and we summarise their role in cancer development and progression.

Keywords

Tumor microenvironmentHypoxia (environmental)EffectorCancer researchPhenotypeBiologyCancer cellImmune systemHypoxia-inducible factorsTumour heterogeneityCancerCell biologyImmunologyChemistryGeneticsGene

Affiliated Institutions

Related Publications

Publication Info

Year
2018
Type
review
Volume
7
Issue
1
Pages
10-10
Citations
994
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

994
OpenAlex

Cite This

Varvara Petrova, Margherita Annicchiarico‐Petruzzelli, Gerry Melino et al. (2018). The hypoxic tumour microenvironment. Oncogenesis , 7 (1) , 10-10. https://doi.org/10.1038/s41389-017-0011-9

Identifiers

DOI
10.1038/s41389-017-0011-9