Abstract

Abstract Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.

Keywords

Extracellular matrixStromal cellMetastasisCell biologyCancer researchTumor microenvironmentCell migrationDesmoplasiaTumour heterogeneityBiologyPathologyCellStromaMedicineTumor cellsCancerImmunohistochemistryBiochemistry

MeSH Terms

AnimalsCell TransformationNeoplasticExtracellular MatrixHumansNeoplasmsTumor Microenvironment

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Publication Info

Year
2020
Type
review
Volume
11
Issue
1
Pages
5120-5120
Citations
1981
Access
Closed

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Cite This

Juliane Winkler, Abisola Abisoye-Ogunniyan, Kevin J. Metcalf et al. (2020). Concepts of extracellular matrix remodelling in tumour progression and metastasis. Nature Communications , 11 (1) , 5120-5120. https://doi.org/10.1038/s41467-020-18794-x

Identifiers

DOI
10.1038/s41467-020-18794-x
PMID
33037194
PMCID
PMC7547708

Data Quality

Data completeness: 90%