Abstract

Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tumor growth, angiogenesis, invasion and metastasis, along with extracellular matrix (ECM) remodeling and even chemoresistance. Numerous previous studies have confirmed the critical role of the interaction between CAFs and tumor cells in tumorigenesis and development. However, recently, the mutual effects of CAFs and the tumor immune microenvironment (TIME) have been identified as another key factor in promoting tumor progression. The TIME mainly consists of distinct immune cell populations in tumor islets and is highly associated with the antitumor immunological state in the TME. CAFs interact with tumor-infiltrating immune cells as well as other immune components within the TIME via the secretion of various cytokines, growth factors, chemokines, exosomes and other effector molecules, consequently shaping an immunosuppressive TME that enables cancer cells to evade surveillance of the immune system. In-depth studies of CAFs and immune microenvironment interactions, particularly the complicated mechanisms connecting CAFs with immune cells, might provide novel strategies for subsequent targeted immunotherapies. Herein, we shed light on recent advances regarding the direct and indirect crosstalk between CAFs and infiltrating immune cells and further summarize the possible immunoinhibitory mechanisms induced by CAFs in the TME. In addition, we present current related CAF-targeting immunotherapies and briefly describe some future perspectives on CAF research in the end.

Keywords

Tumor microenvironmentImmune systemBiologyStromal cellCancer-Associated FibroblastsChemokineCrosstalkCancer researchAngiogenesisTumor progressionImmunologyCell biologyCancer

MeSH Terms

Adaptive ImmunityAnimalsBiomarkersTumorCancer-Associated FibroblastsCell CommunicationDisease SusceptibilityGene Expression RegulationHumansImmune SystemImmunityInnateLymphocytesTumor-InfiltratingNeoplasm GradingNeoplasm MetastasisNeoplasmsSignal TransductionTumor MicroenvironmentTumor-Associated Macrophages

Affiliated Institutions

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Publication Info

Year
2021
Type
review
Volume
20
Issue
1
Pages
131-131
Citations
2011
Access
Closed

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2011
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Cite This

Xiaoqi Mao, Jin Xu, Wei Wang et al. (2021). Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Molecular Cancer , 20 (1) , 131-131. https://doi.org/10.1186/s12943-021-01428-1

Identifiers

DOI
10.1186/s12943-021-01428-1
PMID
34635121
PMCID
PMC8504100

Data Quality

Data completeness: 90%