UCSF Helen Diller Family Comprehensive Cancer Center

The Immune Landscape of Cancer

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identi...

Hepatocellular carcinoma

Liver cancer remains a global health challenge, with an estimated incidence of >1 million cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cance...

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancer...

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

In this international study of CAR T-cell therapy in relapsed or refractory diffuse large B-cell lymphoma in adults, high rates of durable responses were produced with the use o...

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

A framework for advancing our understanding of cancer-associated fibroblasts

Distinct Sets of Genetic Alterations in Melanoma

The genetic alterations identified in melanomas at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development...

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

Metastasis is driven by sequential elevation of H-ras and Smad2 levels