Soft Tissue Sarcoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology

Abstract

Soft tissue sarcomas (STS) are rare malignancies of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Soft Tissue Sarcoma provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as retroperitoneal/intra-abdominal STS, desmoid tumors, and rhabdomyosarcoma. This portion of the NCCN Guidelines discusses general principles for the diagnosis and treatment of retroperitoneal/intra-abdominal STS, outlines treatment recommendations, and reviews the evidence to support the guidelines recommendations.

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Affiliated Institutions

• UCSF Helen Diller Family Comprehensive Cancer Center US
• Breast Cancer Research Foundation US
• University of Tennessee Health Science Center US
• University of Utah US
• Huntsman Cancer Institute US
• City Of Hope National Medical Center US
• O'Neal Comprehensive Cancer Center
• Duke Cancer Institute
• Sidney Kimmel Comprehensive Cancer Center US
• University of California, Davis US
• Stanford Cancer Institute
• University of Pennsylvania US
• Barnes-Jewish Hospital US
• St. Jude Children's Research Hospital US
• Susan Thompson Buffett Foundation US
• Seattle Cancer Care Alliance US
• Cancer Research Center US
• Fred and Pamela Buffett Cancer Center
• Robert Morris University Illinois US
• Vanderbilt-Ingram Cancer Center
• Cleveland Clinic US
• Massachusetts General Hospital US
• The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute US
• University of Colorado Cancer Center US
• Fred Hutch Cancer Center US
• Moores Cancer Center
• University of California, San Diego US
• Moffitt Cancer Center US
• UCLA Jonsson Comprehensive Cancer Center
• University of Colorado Denver US
• Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa ZA
• University Hospitals Seidman Cancer Center US
• University of Michigan US
• Fox Chase Cancer Center US
• The University of Texas Southwestern Medical Center US
• University of Wisconsin Carbone Cancer Center US
• Robert H. Lurie Comprehensive Cancer Center of Northwestern University
• Cancer Institute (WIA) IN
• UC Davis Comprehensive Cancer Center
• Jewish Hospital US
• Kettering University US
• Memorial Sloan Kettering Cancer Center US
• National Comprehensive Cancer Network

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