Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

Abstract

This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Colon Cancer focuses on systemic therapy options for the treatment of metastatic colorectal cancer (mCRC), because important updates have recently been made to this section. These updates include recommendations for first-line use of checkpoint inhibitors for mCRC, that is deficient mismatch repair/microsatellite instability-high, recommendations related to the use of biosimilars, and expanded recommendations for biomarker testing. The systemic therapy recommendations now include targeted therapy options for patients with mCRC that is HER2-amplified, or BRAF V600E mutation–positive. Treatment and management of nonmetastatic or resectable/ablatable metastatic disease are discussed in the complete version of the NCCN Guidelines for Colon Cancer available at NCCN.org . Additional topics covered in the complete version include risk assessment, staging, pathology, posttreatment surveillance, and survivorship.

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Affiliated Institutions

• UCSF Helen Diller Family Comprehensive Cancer Center US
• Breast Cancer Research Foundation US
• University of Utah US
• University of Tennessee Health Science Center US
• Huntsman Cancer Institute US
• City Of Hope National Medical Center US
• O'Neal Comprehensive Cancer Center
• Duke Cancer Institute
• Dana-Farber Brigham Cancer Center US
• Sidney Kimmel Comprehensive Cancer Center US
• Stanford Cancer Institute
• The University of Texas MD Anderson Cancer Center US
• Barnes-Jewish Hospital US
• University of Pennsylvania US
• Susan Thompson Buffett Foundation US
• Seattle Cancer Care Alliance US
• Harold C. Simmons Comprehensive Cancer Center
• Cancer Research Center US
• Fred and Pamela Buffett Cancer Center
• Vanderbilt-Ingram Cancer Center
• Smilow Cancer Hospital US
• Cleveland Clinic US
• Massachusetts General Hospital US
• The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute US
• University of Colorado Cancer Center US
• Fred Hutch Cancer Center US
• University of California, San Diego US
• University of Michigan US
• Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa ZA
• University of Colorado Denver US
• UCLA Jonsson Comprehensive Cancer Center
• Moffitt Cancer Center US
• University Hospitals Seidman Cancer Center US
• Fox Chase Cancer Center US
• The University of Texas Southwestern Medical Center US
• Robert H. Lurie Comprehensive Cancer Center of Northwestern University
• University of Wisconsin Carbone Cancer Center US
• Cancer Institute (WIA) IN
• Jewish Hospital US
• Kettering University US
• Memorial Sloan Kettering Cancer Center US
• National Comprehensive Cancer Network

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