Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Keywords

microRNABiologyMessenger RNAGene expressionDNA microarrayUntranslated regionGeneDownregulation and upregulationGene silencingRegulation of gene expressionThree prime untranslated regionMicroarray analysis techniquesRNAMicroarrayCell biologyGeneticsComputational biology

Affiliated Institutions

Related Publications

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob A. O’Brien , Heyam Hayder , Yara Zayed +1 more

MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating gene expression. The majority of miRNAs are transcribed from DNA sequences into primary...

2018 Frontiers in Endocrinology 4825 citations

Frequent deletions and down-regulation of micro- RNA genes <i>miR15</i> and <i>miR16</i> at 13q14 in chronic lymphocytic leukemia

George A. Calin , Calin Dan Dumitru , Masayoshi Shimizu +12 more

Micro-RNAs ( miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as sh...

2002 Proceedings of the National Academy o... 4969 citations

miR-200b mediates post-transcriptional repression of ZFHX1B

Nanna R. Christoffersen , Asli Silahtaroglu , Ulf Andersson Ørom +2 more

MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their cognate mRNA targets. ZFHX1B is a transcriptional r...

2007 RNA 167 citations

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

Chang‐Gong Liu , George A. Calin , Brian Meloon +11 more

MicroRNAs (miRNAs) are a class of small noncoding RNA genes recently found to be abnormally expressed in several types of cancer. Here, we describe a recently developed methodol...

2004 Proceedings of the National Academy o... 942 citations

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

Chryssa Kanellopoulou , Stefan A. Muljo , Andrew L. Kung +5 more

Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post...

2005 Genes & Development 1237 citations

Publication Info

Year: 2005
Type: article
Volume: 433
Issue: 7027
Pages: 769-773
Citations: 4742
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

4742

OpenAlex

Cite This

APA Style

                            
                                
                                    Lee P. Lim, 
                                
                                    Nelson C. Lau, 
                                
                                    Philip W. Garrett-Engele
                                
                                et al.
                            
                            (2005). 
                            Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. 
                            Nature
                            , 433
                            (7027)
                            , 769-773.
                            https://doi.org/10.1038/nature03315
                        

Identifiers

DOI: 10.1038/nature03315