Integrative Analysis of the <i>Caenorhabditis elegans</i> Genome by the modENCODE Project

Abstract

From Genome to Regulatory Networks For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used to help to produce a functional organism (see the Perspective by Blaxter ). In this vein, Gerstein et al. (p. 1775 ) summarize for the Caenorhabditis elegans genome, and The modENCODE Consortium (p. 1787 ) summarize for the Drosophila melanogaster genome, full transcriptome analyses over developmental stages, genome-wide identification of transcription factor binding sites, and high-resolution maps of chromatin organization. Both studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized. Overall, the studies provide insights into the organization, structure, and function of the two genomes and provide basic information needed to guide and correlate both focused and genome-wide studies.

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Affiliated Institutions

• University of California, Berkeley US
• Harvard University US
• Max Planck Institute of Molecular Cell Biology and Genetics DE
• Lawrence Berkeley National Laboratory US
• University of Cambridge GB
• Cold Spring Harbor Laboratory US
• Yale University US
• University of New Brunswick CA
• Rockefeller University US
• University of Toronto CA
• North Seattle College US
• Wellcome Trust GB
• Howard Hughes Medical Institute US
• University of North Carolina at Chapel Hill US
• State University of New York US
• La Roche College US
• Weizmann Institute of Science IL
• National Human Genome Research Institute US
• National Institutes of Health US
• Stanford Medicine US
• Max Planck Institute for Developmental Biology DE
• Max Delbrück Center DE
• University of California, Santa Cruz US
• Fred Hutch Cancer Center US
• Stanford University US
• Ontario Institute for Cancer Research CA
• Canada Research Chairs CA
• University of California, San Diego US
• University of Michigan US
• Dana-Farber Cancer Institute US
• The Gurdon Institute GB
• Vanderbilt University US
• Max Planck Society DE
• New York University US
• University of Washington US
• Friedrich Miescher Laboratory DE
• Whitney Museum of American Art US
• Kettering University US
• Stony Brook University US

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